Article
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
Science (New York, N.Y.) - 24 May 1996
Novelli M R, Williamson J A, Tomlinson I P, Elia G, Hodgson S V, Talbot I C, Bodmer W F, Wright N A
Abstract excerpt
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large...
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