Article
Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens.
Immunology - 1 Apr 2010
Kang Hee Gyung, Lee Jung Eun, Yang Seung Hee, Lee Se Han, Gao Wenda, Strom Terry B, Oh Keunhee, Lee Dong-Sup, Kim Yon Su
Abstract excerpt
The maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and immature DCs were...
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