Article
Organ-derived dendritic cells have differential effects on alloreactive T cells.
Blood - 1 Mar 2008
Kim Theo D, Terwey Theis H, Zakrzewski Johannes L, Suh David, Kochman Adam A, Chen Megan E, King Chris G, Borsotti Chiara, Grubin Jeremy, Smith Odette M, Heller Glenn, Liu Chen, Murphy George F, Alpdogan Onder, van den Brink Marcel R M
Abstract excerpt
Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer of CFSE-labeled cells, we first demonstrated that alloreactive T cells differentially up-regulate...
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