Article
Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell infusion in mice.
Transplantation - 15 Oct 2009
Dai Hong, Zhu Huifen, Lei Ping, Yagita Hideo, Liu Jing, Wen Xue, Zhou Wei, Gong Feili, Shen Guanxin, Fang Min
Abstract excerpt
BACKGROUND: Alternatively activated dendritic cell (aaDC) can prolong allograft survival in the mouse model. However, the molecular mechanism(s) by which these DCs function to regulate alloreactive T-cell responses remains to be clearly defined. METHODS: Bone marrow-derived DCs were incubated in the presence of interleukin (IL)-10 (immature DC), stimulated with lipopolysaccharide only (mature DC), or pretreated...
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