Article
A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival.
Transplantation - 15 Apr 2000
O'Rourke R W, Kang S M, Lower J A, Feng S, Ascher N L, Baekkeskov S, Stock P G
Abstract excerpt
BACKGROUND: Dendritic cells are potent antigen-presenting cells that bind allogeneic T cells. They are thus candidates for targeting immunoregulatory molecules to the alloreactive T cell compartment and suppressing the alloimmune response. METHOD: A dendritic cell line derived from the BALB/c mouse (H2d) was genetically modified to express the immunoregulatory molecule CTLA4-Ig. The ability of these dendritic...
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