Article
Depending on their maturation state, splenic dendritic cells induce the differentiation of CD4(+) T lymphocytes into memory and/or effector cells in vivo.
European journal of immunology - 1 Jul 2004
de Heusch Magali, Oldenhove Guillaume, Urbain Jacques, Thielemans Kris, Maliszewski Charlie, Leo Oberdan, Moser Muriel
Abstract excerpt
There is increasing evidence that dendritic cells (DC) display opposite functions in the immune system, as they may induce immunity or tolerance depending on intrinsic and environmental factors. In mice, adoptive transfer of mature DC pulsed extracorporeally with antigen induces the development of antigen-specific Th1- and Th2-type CD4(+) cells. In this work, we compared the adjuvant properties of immature...
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