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hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts

23 Nov 2020

Abstract excerpt

BACKGROUND: With their inherent capability of unlimited self-renewal and unique potential to differentiate into functional cells of the three germ layers, human embryonic stem cells (hESCs) hold great potential in regenerative medicine. A major challenge in the application of hESC-based cell therapy is the allogeneic immune rejection of hESC-derived allografts. METHODS: We derived dendritic cell-like cells (DCLs)...

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PMID: 33242828
DOI: 10.1016/j.ebiom.2020.103120

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