Alloantigen‐specific <i>de novo‐</i> induced Foxp3 ⁺ Treg revert <i>in vivo</i> and do not protect from experimental GVHD

Abstract excerpt

Induced antigen-specific Foxp3(+) T cells (iTreg) are being discussed as a promising alternative to polyclonal natural Foxp3(+) T cells (nTreg) for cell-based therapies, particularly to achieve transplantation tolerance. Using Foxp3eGFP-reporter mice, we here establish an efficient protocol to induce and expand alloantigen-specific iTreg from Foxp3(-)CD4(+) T cells with cluster-disrupted DC. These iTreg were...

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