Article
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006
Yamazaki Sayuri, Patel Munjal, Harper Alice, Bonito Anthony, Fukuyama Hidehiro, Pack Maggi, Tarbell Kristin V, Talmor Mia, Ravetch Jeffrey V, Inaba Kayo, Steinman Ralph M
Abstract excerpt
Thymic-derived CD25+ CD4+ T regulatory cells (Tregs) suppress immune responses, including transplantation. Here we evaluated the ability of dendritic cells (DCs) to expand alloantigen-specific Tregs in the mixed leukocyte reaction (MLR) that develops from polyclonal populations of T cells. The allogeneic DCs, when supplemented with IL-2 in the cultures, were much more effective than bulk spleen cells in expanding...
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