Article
Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced anti-viral therapeutic effects.
Scientific reports - 13 Dec 2016
Zhou Qianqian, Zhang Yulong, Zhao Man, Wang Xiaohui, Ma Cong, Jiang Xinquan, Wu Tao, Wang Donggen, Zhan Linsheng
Abstract excerpt
Cryopreservation is critical in reducing redundant operations and also in quality control in dendritic cell (DC) therapy. Full maturation and efficient homing of DCs to T cell-region constitute a crucial aspect of DC immunotherapy; however, the in vivo migration and distribution pattern, as well as the anti-viral effect of DCs that matured from cryopreserved immature DCs (cryoim-mDCs) remain to be revealed. In...
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