Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular progression of plutonium-239-induced rat lung carcinogenesis: Ki-ras expression and activation.

Molecular carcinogenesis - 1 Jan 1991

Stegelmeier B L, Gillett N A, Rebar A H, Kelly G

Abstract excerpt

Specific, transforming point mutations of ras and alterations in ras expression have been associated with many neoplastic processes, and their presence may be pivotal in neoplastic transformation. Our objective were to evaluate the molecular and genetic alterations of Ki-ras in preneoplastic foci and neoplasms in the lungs of rats that inhaled 239PuO2 aerosols. Histologically classified pulmonary lesions were...

Topics

Animals
Autoradiography
Base Sequence
DNA Probes
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Lung Neoplasms
Molecular Sequence Data
Mutation
Plutonium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred F344

Source

Identifiers

PMID: 2009134
DOI: 10.1002/mc.2940040108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2009134-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular progression of plutonium-239-induced rat lung carcinogenesis: Ki-ras expression and activation.PMID 2009134Read ↗

K-ras mutations in 239PuO2 canine lung neoplasms.Semantic proximity Read ↗

Alterations in the K-ras and p53 genes in rat lung tumors.Semantic proximity Read ↗

Activated Ki-ras proto-oncogene in spontaneously transformed and chemical tumor-derived cell lines related to the mouse lung alveologenic carcinoma.Semantic proximity Read ↗

Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice.Semantic proximity Read ↗

Ki-ras activation and expression in transformed mouse lung cell lines.Semantic proximity Read ↗

Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice.Semantic proximity Read ↗

Mutations in Tp53 gene sequences from lung tumors in rats that inhaled plutonium dioxide.Semantic proximity Read ↗

Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats.Semantic proximity Read ↗

Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice.Semantic proximity Read ↗

Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.Semantic proximity Read ↗

Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors.Semantic proximity Read ↗

Nitrative and oxidative DNA damage caused by K-ras mutation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.