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Article

Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice.

Molecular carcinogenesis - 1 Jan 1992

Manam S, Storer R D, Prahalada S, Leander K R, Kraynak A R, Hammermeister C L, Joslyn D J, Ledwith B J, van Zwieten M J, Bradley M O

Abstract excerpt

As part of an evaluation of the effectiveness of using ras mutation analysis for distinguishing carcinogen-induced from spontaneous tumors, we examined the profile of ras gene point mutations in spontaneous, 7,12-dimethylbenz[a]anthracene (DMBA)-induced, and N-nitrosodiethylamine (DEN)-induced lung tumors from Crl:CD-1(ICR)BR (CD-1) mice. Although all of the lung tumors were assayed for mutations in the Ha-ras,...

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Identifiers

PMID: 1503645
DOI: 10.1002/mc.2940060111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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