Article
Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice.
Molecular carcinogenesis - 1 Jan 1992
Manam S, Storer R D, Prahalada S, Leander K R, Kraynak A R, Hammermeister C L, Joslyn D J, Ledwith B J, van Zwieten M J, Bradley M O
Abstract excerpt
As part of an evaluation of the effectiveness of using ras mutation analysis for distinguishing carcinogen-induced from spontaneous tumors, we examined the profile of ras gene point mutations in spontaneous, 7,12-dimethylbenz[a]anthracene (DMBA)-induced, and N-nitrosodiethylamine (DEN)-induced lu...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- DNA Mutational Analysis
- Diethylnitrosamine
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Hydroxyacetylaminofluorene
- Lung Neoplasms
- Mice
- Mice, Inbred Strains
- Mutation
- Transcriptional Activation
- Transfection
- p-Aminoazobenzene