Article
Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats.
Lung - 1 Jan 2000
Igarashi Maki, Yoshida Midori, Watanabe Manabu, Yamada Toshiyuki, Sakurai Takuya, Endo Yoshifumi, Miyajima Nozomi, Maekawa Akihiko, Oikawa Tsuneyuki, Sugano Sumio, Nakae Dai
Abstract excerpt
In this study we investigated the Ser33 phosphorylation status of beta-catenin protein in relation to genomic mutations in lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in male Fischer 344 rats. Six-week-old animals received 2000 ppm of BHP in the drinking water for 8 weeks and were sacrificed 12 weeks thereafter. Histopathologically, 69 of 75 rats demonstrated multiple lung...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.