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Nitrative and oxidative DNA damage caused by K-ras mutation in mice.

Biochemical and biophysical research communications - 23 Sept 2011

Ohnishi Shiho, Saito Hiromitsu, Suzuki Noboru, Ma Ning, Hiraku Yusuke, Murata Mariko, Kawanishi Shosuke

Abstract excerpt

Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using conditional transgenic mice. Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by...

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Source

Identifiers

PMID: 21875576
DOI: 10.1016/j.bbrc.2011.08.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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