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Mutations in Tp53 gene sequences from lung tumors in rats that inhaled plutonium dioxide.

Radiation research - 1 Dec 1999

Yamada Y, Oghiso Y

Abstract excerpt

We investigated mutations of the Tp53 tumor suppressor gene (formerly known as p53) in the lung tumors induced in rats after inhalation of plutonium dioxide ((239)PuO(2)) aerosols. Exons 5, 6, 7 and 8 of the Tp53 gene were examined for mutations by single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified fragments and direct sequencing analysis. Almost all the mutations...

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PMID: 10564948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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