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Article

Alterations in the K-ras and p53 genes in rat lung tumors.

Environmental health perspectives - 1 Jun 1997

Belinsky S A, Swafford D S, Finch G L, Mitchell C E, Kelly G, Hahn F F, Anderson M W, Nikula K J

Abstract excerpt

Activation of the K-ras protooncogene and inactivation of the p53 tumor suppressor gene are events common to many types of human cancers. Molecular epidemiology studies have associated mutational profiles in these genes with specific exposures. The purpose of this paper is to review investigations that have examined the role of the K-ras and p53 genes in lung tumors induced in the F344 rat by mutagenic and...

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Identifiers

PMID: 9255578
DOI: 10.1289/ehp.97105s4901
PMCID: PMC1470039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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