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Article

The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments.

Circulation research - 5 Mar 2010

Galińska Agnieszka, Hatch Victoria, Craig Roger, Murphy Anne M, Van Eyk Jennifer E, Wang C-L Albert, Lehman William, Foster D Brian

Abstract excerpt

RATIONALE: Ca(2+) control of troponin-tropomyosin position on actin regulates cardiac muscle contraction. The inhibitory subunit of troponin, cardiac troponin (cTn)I is primarily responsible for maintaining a tropomyosin conformation that prevents crossbridge cycling. Despite extensive characterization of cTnI, the precise role of its C-terminal domain (residues 193 to 210) is unclear. Mutations within this...

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Identifiers

PMID: 20035081
DOI: 10.1161/CIRCRESAHA.109.210047
PMCID: PMC2834238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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