Article
The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments.
Circulation research - 5 Mar 2010
Galińska Agnieszka, Hatch Victoria, Craig Roger, Murphy Anne M, Van Eyk Jennifer E, Wang C-L Albert, Lehman William, Foster D Brian
Abstract excerpt
RATIONALE: Ca(2+) control of troponin-tropomyosin position on actin regulates cardiac muscle contraction. The inhibitory subunit of troponin, cardiac troponin (cTn)I is primarily responsible for maintaining a tropomyosin conformation that prevents crossbridge cycling. Despite extensive characterization of cTnI, the precise role of its C-terminal domain (residues 193 to 210) is unclear. Mutations within this...
Topics
- Actin Cytoskeleton
- Animals
- Binding Sites
- Calcium
- Cattle
- Humans
- Imaging, Three-Dimensional
- Microscopy, Electron
- Models, Molecular
- Multiprotein Complexes
- Mutation
- Myocardial Contraction
- Myocardium