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Article

Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C.

Journal of molecular biology - 25 Jun 2021

Mahmud Zabed, Dhami Prabhpaul S, Rans Caleb, Liu Philip B, Hwang Peter M

Abstract excerpt

Cardiac troponin (cTn) is made up of three subunits, cTnC, cTnI, and cTnT. The regulatory N-terminal domain of cTnC (cNTnC) controls cardiac muscle contraction in a calcium-dependent manner. We show that calcium-saturated cNTnC can adopt two different orientations, with the "active" orientation consistent with the 2020 cryo-EM structure of the activated cardiac thin filament by Yamada et al. Using solution NMR...

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Identifiers

PMID: 33901537
DOI: 10.1016/j.jmb.2021.167010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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