Article
TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2020
Madan Aditi, Viswanathan Meera C, Woulfe Kathleen C, Schmidt William, Sidor Agnes, Liu Ting, Nguyen Tran H, Trinh Bosco, Wilson Cortney, Madathil Sineej, Vogler Georg, O'Rourke Brian, Biesiadecki Brandon J, Tobacman Larry S, Cammarato Anthony
Abstract excerpt
Muscle contraction is regulated by the movement of end-to-end-linked troponin-tropomyosin complexes over the thin filament surface, which uncovers or blocks myosin binding sites along F-actin. The N-terminal half of troponin T (TnT), TNT1, independently promotes tropomyosin-based, steric inhibition of acto-myosin associations, in vitro. Recent structural models additionally suggest TNT1 may restrain the uniform,...
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