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Article

Dynamics of the C-terminal region of TnI in the troponin complex in solution.

Biophysical journal - 1 Apr 2006

Blumenschein Tharin M A, Stone Deborah B, Fletterick Robert J, Mendelson Robert A, Sykes Brian D

Abstract excerpt

The determination of crystal structures of the troponin complex (Takeda et al. 2003. Nature. 424:35-41; Vinogradova et al. 2005. Proc. Natl. Acad. Sci. USA. 102:5038-5043) has advanced knowledge of the regulation of muscle contraction at the molecular level. However, there are domains important for actin binding that are not visualized. We present evidence that the C-terminal region of troponin I (TnI residues...

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Identifiers

PMID: 16415057
DOI: 10.1529/biophysj.105.076216
PMCID: PMC1403181

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