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Article

Role of cardiac troponin I carboxy terminal mobile domain and linker sequence in regulating cardiac contraction.

Archives of biochemistry and biophysics - 1 Jul 2016

Meyer Nancy L, Chase P Bryant

Abstract excerpt

Inhibition of striated muscle contraction at resting Ca(2+) depends on the C-terminal half of troponin I (TnI) in thin filaments. Much focus has been on a short inhibitory peptide (Ip) sequence within TnI, but structural studies and identification of disease-associated mutations broadened emphasis to include a larger mobile domain (Md) sequence at the C-terminus of TnI. For Md to function effectively in muscle...

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Identifiers

PMID: 26971468
DOI: 10.1016/j.abb.2016.03.010
PMCID: PMC4899117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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