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Article

Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium.

The Journal of biological chemistry - 20 Dec 2019

Johnson Dylan, Zhu Li, Landim-Vieira Maicon, Pinto Jose Renato, Chalovich Joseph M

Abstract excerpt

Striated muscle is activated by myosin- and actin-linked processes, with the latter being regulated through changes in the position of tropomyosin relative to the actin surface. The C-terminal region of cardiac troponin T (TnT), a tropomyosin-associated protein, is required for full TnT inactivation at low Ca2+ and for limiting its activation at saturating Ca2+ Here, we investigated whether basic residues in this...

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Identifiers

PMID: 31712308
DOI: 10.1074/jbc.RA119.010966
PMCID: PMC6926443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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