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Article

Resolving the structure and dynamics of the disordered C terminus of human cardiac troponin T and effects of cardiomyopathic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 2025

Crosby Garrett S, Hei Bai, Lynn Melissa L, Chakraborti Ananya, Schwartz Steven D, Tardiff Jil C

Abstract excerpt

The C-terminal tail of cardiac troponin T (C-cTnT) inhibits thin filament activation and is a hotspot for cardiomyopathic mutations and variants. The mechanism whereby this region limits activation is not well understood. The last 16 C-terminal residues form a highly flexible and disordered domain and thus have been poorly resolved in studies to date. Using Time-Resolved fluorescence resonance energy transfer...

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Identifiers

PMID: 40627400
DOI: 10.1073/pnas.2425343122
PMCID: PMC12280962

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