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Article

Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin.

The Journal of general physiology - 1 Mar 2021

Tobacman Larry S, Cammarato Anthony

Abstract excerpt

Reversible Ca2+ binding to troponin is the primary on-off switch of the contractile apparatus of striated muscles, including the heart. Dominant missense mutations in human cardiac troponin genes are among the causes of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Structural understanding of troponin action has recently advanced considerably via electron microscopy and molecular dynamics studies...

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Identifiers

PMID: 33492345
DOI: 10.1085/jgp.202012815
PMCID: PMC7836260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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