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Article

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014

Hwang Peter M, Cai Fangze, Pineda-Sanabria Sandra E, Corson David C, Sykes Brian D

Abstract excerpt

The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac contractility. cTnC contains two EF-hand domains (the N and C domain of cTnC, cNTnC and cCTnC) connected by a flexible...

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Identifiers

PMID: 25246568
DOI: 10.1073/pnas.1410775111
PMCID: PMC4210035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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