Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.

The Journal of biological chemistry - 7 Dec 2012

Kowlessur Devanand, Tobacman Larry S

Abstract excerpt

Ca(2+) dissociation from troponin causes cessation of muscle contraction by incompletely understood structural mechanisms. To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subunit troponin C (TnC) was abolished by mutagenesis, and effects on cardiac troponin dynamics were mapped by hydrogen-deuterium exchange (HDX)-MS. The findings demonstrate the interrelationships among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein Structure, Tertiary
Share to Calcium
Share to Cardiomyopathies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deuterium Exchange Measurement

Share to Genetic Diseases, Inborn

Share to Protein Structure, Secondary

Share to Troponin C

Share to Troponin I

Source

Open in PubMed Open full text

Identifiers

PMID: 23066014
DOI: 10.1074/jbc.M112.423459
PMCID: PMC3516773

Genes

HDX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.PMID 23066014Read ↗

Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin.Semantic proximity Read ↗

Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Semantic proximity Read ↗

Inherited cardiomyopathies caused by troponin mutations.Semantic proximity Read ↗

Troponins, intrinsic disorder, and cardiomyopathy.Semantic proximity Read ↗

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.Semantic proximity Read ↗

Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Semantic proximity Read ↗

[Calcium regulation by troponin and its genetic disorder in striated muscle contraction].Semantic proximity Read ↗

The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments.Semantic proximity Read ↗

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.Semantic proximity Read ↗

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.Semantic proximity Read ↗

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.Semantic proximity Read ↗

Investigating cardiomyopathies with atomistic simulations of cardiac TroponinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.