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Article

Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.

The Journal of biological chemistry - 7 Dec 2012

Kowlessur Devanand, Tobacman Larry S

Abstract excerpt

Ca(2+) dissociation from troponin causes cessation of muscle contraction by incompletely understood structural mechanisms. To investigate this process, regulatory site Ca(2+) binding in the NH(2)-lobe of subunit troponin C (TnC) was abolished by mutagenesis, and effects on cardiac troponin dynamics were mapped by hydrogen-deuterium exchange (HDX)-MS. The findings demonstrate the interrelationships among...

Topics

Calcium
Cardiomyopathies
Deuterium Exchange Measurement
Genetic Diseases, Inborn
Humans
Mutation
Protein Structure, Secondary
Protein Structure, Tertiary
Troponin C
Troponin I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23066014
DOI: 10.1074/jbc.M112.423459
PMCID: PMC3516773

Genes

HDX

Provenance

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