Article
Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans.
Human molecular genetics - 1 Oct 2012
McLaren Paul J, Ripke Stephan, Pelak Kimberly, Weintrob Amy C, Patsopoulos Nikolaos A, Jia Xiaoming, Erlich Rachel L, Lennon Niall J, Kadie Carl M, Heckerman David, Gupta Namrata, Haas David W, Deeks Steven G, Pereyra Florencia, Walker Bruce D, de Bakker Paul I W
Abstract excerpt
A small proportion of human immunodeficiency virus-1 (HIV-1) infected individuals, termed HIV-1 controllers, suppress viral replication to very low levels in the absence of therapy. Genetic investigations of this phenotype have strongly implicated variation in the class I major histocompatibility complex (MHC) region as key to HIV-1 control. We collected sequence-based classical class I HLA genotypes at 4-digit...
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