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Article

Multilayered defense in HLA-B51-associated HIV viral control.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2011

Zhang YongHong, Peng YanChun, Yan HuiPing, Xu Keyi, Saito Masumichi, Wu Hao, Chen XinYue, Ranasinghe Srinika, Kuse Nozomi, Powell Tim, Zhao Yan, Li WeiHua, Zhang Xin, Feng Xia, Li Ning, Leligdowicz Aleksandra, Xu XiaoNing, John Mina, Takiguchi Masafumi, McMichael Andrew, Rowland-Jones Sarah, Dong Tao

Abstract excerpt

Polymorphism in the HLA region of a chromosome is the major source of host genetic variability in HIV-1 outcome, but there is limited understanding of the mechanisms underlying the beneficial effect of protective class I alleles such as HLA-B57, -B27, and -B51. Taking advantage of a unique cohort infected with clade B' HIV-1 through contaminated blood, in which many variables such as the length of infection, the...

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Share to Cytotoxicity, Immunologic
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HLA-B Antigens

Share to HLA-B51 Antigen

Share to Immunodominant Epitopes

Share to pol Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

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Identifiers

PMID: 21670313
DOI: 10.4049/jimmunol.1100316
PMCID: PMC3166850

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