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Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer

1 Dec 2009

Abstract excerpt

BACKGROUND: Alterations of mitochondrial DNA (mtDNA) have been implicated in carcinogenesis. We developed an accurate multiplex quantitative real-time PCR for synchronized determination of mtDNA and nuclear DNA (nDNA). We sought to investigate whether mtDNA content in the peripheral blood of breast cancer patients is associated with clinical and pathological parameters. METHODS: Peripheral blood samples were...

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PMID: 20025731
DOI: 10.1186/1471-2407-9-454

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