Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer.

Cancer research - 15 Jul 2015

Lemnrau Alina, Brook Mark N, Fletcher Olivia, Coulson Penny, Tomczyk Katarzyna, Jones Michael, Ashworth Alan, Swerdlow Anthony, Orr Nick, Garcia-Closas Montserrat

Abstract excerpt

Increased mitochondrial DNA (mtDNA) copy number in peripheral blood cells (PBC) has been associated with the risk of developing several tumor types. Here we evaluate sources of variation of this biomarker and its association with breast cancer risk in a prospective cohort study. mtDNA copy number was measured using quantitative real-time PCR on PBC DNA samples from participants in the UK-based Breakthrough...

Topics

Blood Cells
Breast Neoplasms
Case-Control Studies
DNA Copy Number Variations
DNA, Mitochondrial
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precancerous Conditions

Risk Factors

Source

Identifiers

PMID: 25977328
DOI: 10.1158/0008-5472.CAN-14-1692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer.PMID 25977328Read ↗

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer.Semantic proximity Read ↗

Correlational study on mitochondrial DNA mutations as potential risk factors in breast cancer.Semantic proximity Read ↗

Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancerSemantic proximity Read ↗

Current understanding of mitochondrial DNA in breast cancer.Semantic proximity Read ↗

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumorsSemantic proximity Read ↗

Reduced mitochondrial DNA copy number is associated with the haplogroup, and some clinical features of breast cancer in Mexican patients.Semantic proximity Read ↗

Plasma Circulating Cell-free Nuclear and Mitochondrial DNA as Potential Biomarkers in the Peripheral Blood of Breast Cancer PatientsSemantic proximity Read ↗

Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohortSemantic proximity Read ↗

Alcohol consumption and breast tumor mitochondrial DNA mutations.Semantic proximity Read ↗

Quantitative analysis of plasma circulating DNA at diagnosis and during follow-up of breast cancer patientsSemantic proximity Read ↗

Detection of mitochondrial DNA mutations by high-throughput sequencing in the blood of breast cancer patients.Semantic proximity Read ↗

Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.