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Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer.

Cancer research - 15 Jul 2015

Lemnrau Alina, Brook Mark N, Fletcher Olivia, Coulson Penny, Tomczyk Katarzyna, Jones Michael, Ashworth Alan, Swerdlow Anthony, Orr Nick, Garcia-Closas Montserrat

Abstract excerpt

Increased mitochondrial DNA (mtDNA) copy number in peripheral blood cells (PBC) has been associated with the risk of developing several tumor types. Here we evaluate sources of variation of this biomarker and its association with breast cancer risk in a prospective cohort study. mtDNA copy number was measured using quantitative real-time PCR on PBC DNA samples from participants in the UK-based Breakthrough...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25977328
DOI: 10.1158/0008-5472.CAN-14-1692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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