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Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients

12 Apr 2010

Abstract excerpt

Mutations and reduced mitochondrial DNA (mtDNA) content are commonly observed in breast cancer, yet their functional significance is not clear. This study aimed to determine whether the mtDNA content in breast cancer plays an important role in modulating the response to anthracycline treatment in vivo and in vitro. The mtDNA content in tumor cells was analyzed using quantitative polymerase chain reaction in 60...

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PMID: 20408822
DOI: 10.1111/j.1524-4741.2010.00908.x

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