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Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients

1 Jan 2007

Abstract excerpt

Somatic mutations and large-scale depletion in mitochondrial DNA (mtDNA) have been extensively detected in various human cancers. However, it still remains unclear whether the alterations in mtDNA content are related to the clinicopathological parameters and patient prognosis in breast cancer. In the present study, we analyzed the copy number of mtDNA in 59 cases of invasive breast tumors and paired nontumorous...

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PMID: 17654121
DOI: 10.1080/15216540701509955

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