Article
Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues.
BMC neuroscience - 16 Dec 2009
Wishart Thomas M, Brownstein David G, Thomson Derek, Tabakova Anca M, Boothe Katherine M, Tsao Jack W, Gillingwater Thomas H
Abstract excerpt
BACKGROUND: The slow Wallerian Degeneration (Wld(S)) gene specifically protects axonal and synaptic compartments of neurons from a wide variety of degeneration-inducing stimuli, including; traumatic injury, Parkinson's disease, demyelinating neuropathies, some forms of motor neuron disease and global cerebral ischemia. The Wld(S) gene encodes a novel Ube4b-Nmnat1 chimeric protein (Wld(S) protein) that is...
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