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Article

Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jan 2009

Beirowski Bogdan, Babetto Elisabetta, Gilley Jon, Mazzola Francesca, Conforti Laura, Janeckova Lucie, Magni Giulio, Ribchester Richard R, Coleman Michael P

Abstract excerpt

Axon degeneration contributes widely to neurodegenerative disease but its regulation is poorly understood. The Wallerian degeneration slow (Wld(S)) protein protects axons dose-dependently in many circumstances but is paradoxically abundant in nuclei. To test the hypothesis that Wld(S) acts within nuclei in vivo, we redistributed it from nucleus to cytoplasm in transgenic mice. Surprisingly, instead of weakening...

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Identifiers

PMID: 19158292
DOI: 10.1523/JNEUROSCI.3814-08.2009
PMCID: PMC6665162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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