Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration<i>In Vivo</i>

Abstract excerpt

Axonal degeneration is a key component of a variety of neurological diseases. Studies using wld(s) mutant mice have demonstrated that delaying axonal degeneration slows disease course and prolongs survival in neurodegenerative disease models. The Wld(s) protein is normally localized to the nucleus, and contains the N terminus of ubiquitination factor Ube4b fused to full-length Nmnat1, an NAD biosynthetic enzyme....

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