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Article

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.

Molecular neurodegeneration - 8 Feb 2012

Antenor-Dorsey Jo Ann V, O'Malley Karen L

Abstract excerpt

BACKGROUND: The WldS mouse mutant ("Wallerian degeneration-slow") delays axonal degeneration in a variety of disorders including in vivo models of Parkinson's disease. The mechanisms underlying WldS -mediated axonal protection are unclear, although many studies have attributed WldS neuroprotection to the NAD+-synthesizing Nmnat1 portion of the fusion protein. Here, we used dissociated dopaminergic cultures to...

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Identifiers

PMID: 22315973
DOI: 10.1186/1750-1326-7-5
PMCID: PMC3322348

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