Article
The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Brain : a journal of neurology - 1 Feb 2005
Mi Weiqian, Beirowski Bogdan, Gillingwater Thomas H, Adalbert Robert, Wagner Diana, Grumme Daniela, Osaka Hitoshi, Conforti Laura, Arnhold Stefan, Addicks Klaus, Wada Keiji, Ribchester Richard R, Coleman Michael P
Abstract excerpt
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss remains uncertain....
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