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Article

Axon pathology in neurological disease: a neglected therapeutic target.

Trends in neurosciences - 1 Oct 2002

Coleman Michael P, Perry V Hugh

Abstract excerpt

In the C57BL/Wld(S) mouse, a dominant mutation dramatically delays Wallerian degeneration in injury and disease, possibly by influencing multi-ubiquitination. Studies on this mouse show that axons and synapses degenerate by active and regulated mechanisms that are akin to apoptosis. Axon loss con...

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Source

Identifiers

PMID: 12220882
DOI: 10.1016/s0166-2236(02)02255-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12220882-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Axon pathology in neurological disease: a neglected therapeutic target.PMID 12220882Read ↗

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