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Article

Polyphosphate binds with high affinity to exosite II of thrombin.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2010

Mutch N J, Myles T, Leung L L K, Morrissey J H

Abstract excerpt

BACKGROUND: Polyphosphate (a linear polymer of inorganic phosphate) is secreted from platelet dense granules, and we recently showed that it accelerates factor V activation by thrombin. OBJECTIVE: To examine the interaction of polyphosphate with thrombin. METHODS AND RESULTS: Thrombin, but not pr...

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Identifiers

PMID: 20002544
DOI: 10.1111/j.1538-7836.2009.03723.x
PMCID: PMC2856763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20002544-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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