Article
Beta2-glycoprotein I binds thrombin via exosite I and exosite II: anti-beta2-glycoprotein I antibodies potentiate the inhibitory effect of beta2-glycoprotein I on thrombin-mediated factor XIa generation.
Arthritis and rheumatism - 1 Feb 2007
Rahgozar Soheila, Yang Qiuxia, Giannakopoulos Bill, Yan Xiaokai, Miyakis Spiros, Krilis Steven A
Abstract excerpt
OBJECTIVE: Beta(2)-glycoprotein I (beta(2)GPI) is a dominant antigenic target in antiphospholipid syndrome (APS). Beta(2)-glycoprotein I may bind to factor XI and serve a physiologic function as a regulator of factor XI activation by thrombin. We undertook this study to investigate the possible interactions of beta(2)GPI with thrombin in beta(2)GPI-regulated factor XI activation by thrombin and to evaluate the...
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