Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans.

Article

Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans.

The Journal of biological chemistry - 30 Dec 1994

Sheehan J P, Tollefsen D M, Sadler J E

Abstract excerpt

Besides its critical role in hemostasis, the serine protease thrombin also participates in wound healing, inflammation, and atherosclerosis. Thrombin is inhibited by the serpins antithrombin and heparin cofactor II (HCiI) in reactions that are accelerated markedly by specific glycosaminoglycans....

Topics

Allosteric Regulation
Dermatan Sulfate
Glycosaminoglycans
Heparin
Heparin Cofactor II
Humans
Mutation
Recombinant Proteins
Sepharose
Templates, Genetic
Thrombin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.