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Article

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.

Science (New York, N.Y.) - 11 Jul 2003

Celikel Reha, McClintock Richard A, Roberts James R, Mendolicchio G Loredana, Ware Jerry, Varughese Kottayil I, Ruggeri Zaverio M

Abstract excerpt

Thrombin bound to platelets contributes to stop bleeding and, in pathological conditions, may cause vascular thrombosis. We have determined the structure of platelet glycoprotein Ibalpha (GpIbalpha) bound to thrombin at 2.3 angstrom resolution and defined two sites in GpIbalpha that bind to exosite II and exosite I of two distinct alpha-thrombin molecules, respectively. GpIbalpha occupancy may be sequential, as...

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Source

Identifiers

PMID: 12855810
DOI: 10.1126/science.1084183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.PMID 12855810Read ↗

Platelet adhesion: a game of catch and release.Semantic proximity Read ↗

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.Semantic proximity Read ↗

β2 -Glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions.Semantic proximity Read ↗

Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively.Semantic proximity Read ↗

Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects.Semantic proximity Read ↗

Interaction between GPIbalpha and FcgammaIIA receptor in human platelets.Semantic proximity Read ↗

Beta2-glycoprotein I binds thrombin via exosite I and exosite II: anti-beta2-glycoprotein I antibodies potentiate the inhibitory effect of beta2-glycoprotein I on thrombin-mediated factor XIa generation.Semantic proximity Read ↗

Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations.Semantic proximity Read ↗

Molecular mapping of the thrombin-heparin cofactor II complex.Semantic proximity Read ↗

Inhibition of a thrombin anion-binding exosite-2 mutant by the glycosaminoglycan-dependent serpins protein C inhibitor and heparin cofactor II.Semantic proximity Read ↗

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-BSemantic proximity Read ↗

Identification of a novel 14-3-3zeta binding site within the cytoplasmic domain of platelet glycoprotein Ibalpha that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX.Semantic proximity Read ↗

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