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Article

The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

The Journal of biological chemistry - 7 Jul 2006

Bukys Michael A, Orban Tivadar, Kim Paul Y, Beck Daniel O, Nesheim Michael E, Kalafatis Michael

Abstract excerpt

Alpha-thrombin has two separate electropositive binding exosites (anion binding exosite I, ABE-I and anion binding exosite II, ABE-II) that are involved in substrate tethering necessary for efficient catalysis. Alpha-thrombin catalyzes the activation of factor V and factor VIII following discrete proteolytic cleavages. Requirement for both anion binding exosites of the enzyme has been suggested for the activation...

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Identifiers

PMID: 16624813
DOI: 10.1074/jbc.M600752200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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