Article
β2 -Glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2013
Pozzi N, Acquasaliente L, Frasson R, Cristiani A, Moro S, Banzato A, Pengo V, Scaglione G L, Arcovito A, De Cristofaro R, De Filippis V
Abstract excerpt
BACKGROUND: This work was aimed at characterizing the interaction of β(2)-glycoprotein I (β(2)GPI), an abundant plasma protein of unknown function, with human thrombin, the final effector protease in the coagulation cascade. METHODS: The β(2)GPI-thrombin interaction was studied by surface plasmon resonance (SPR), fluorescence, and molecular modeling. The effect of β(2)GPI on the procoagulant (fibrin generation...
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