Article
The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.
The Journal of biological chemistry - 30 Jan 2004
Bianchini Elsa P, Pike Robert N, Le Bonniec Bernard F
Abstract excerpt
A number of studies suggest that blood-clotting factor X (FX) uses secondary site(s) to interact (as a substrate) with its activators. Numerous pieces of evidence also imply that, within prothrombinase (as an enzyme), activated FX (FXa) uses exosite(s) for cofactor Va and/or prothrombin recognition. Similarly, FXa exosite(s) seem to govern interaction with inhibitors. An obvious difference between FXa and...
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