Amino acid residues of heparin cofactor II required for stimulation of thrombin inhibition by sulphated polyanions.

doi:10.1016/s0167-4838(99)00051-5

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Article

Amino acid residues of heparin cofactor II required for stimulation of thrombin inhibition by sulphated polyanions.

Biochimica et biophysica acta - 12 Apr 1999

Colwell N S, Grupe M J, Tollefsen D M

Abstract excerpt

A variety of sulphated polyanions in addition to heparin and dermatan sulphate stimulate the inhibition of thrombin by heparin cofactor II (HCII). Previous investigations indicated that the binding sites on HCII for heparin and dermatan sulphate overlap but are not identical. In this study we determined the concentrations (IC50) of various polyanions required to stimulate thrombin inhibition by native recombinant...

Topics

Amino Acids
Binding Sites
Heparin Cofactor II
Mutation
Polyelectrolytes
Polymers
Recombinant Proteins
Thrombin

Source

Open in PubMed

Identifiers

PMID: 10209287
DOI: 10.1016/s0167-4838(99)00051-5

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