Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection.

Nature communications - 6 Sept 2016

Labberton Linda, Kenne Ellinor, Long Andy T, Nickel Katrin F, Di Gennaro Antonio, Rigg Rachel A, Hernandez James S, Butler Lynn, Maas Coen, Stavrou Evi X, Renné Thomas

Abstract excerpt

Polyphosphate is an inorganic procoagulant polymer. Here we develop specific inhibitors of polyphosphate and show that this strategy confers thromboprotection in a factor XII-dependent manner. Recombinant Escherichia coli exopolyphosphatase (PPX) specifically degrades polyphosphate, while a PPX variant lacking domains 1 and 2 (PPX_Δ12) binds to the polymer without degrading it. Both PPX and PPX_Δ12 interfere with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Anhydride Hydrolases
Share to Blood Coagulation Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor XII

Share to Platelet Aggregation

Share to Polyphosphates

Share to Protein Domains

Share to Thrombin

Share to Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 27596064
DOI: 10.1038/ncomms12616
PMCID: PMC5025862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection.PMID 27596064Read ↗

Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride is a Safe and Effective Antithrombotic TherapySemantic proximity Read ↗

Polyphosphate binds with high affinity to exosite II of thrombin.Semantic proximity Read ↗

Platelet-delivered therapeutics.Semantic proximity Read ↗

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopeniaSemantic proximity Read ↗

Engineered human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo.Semantic proximity Read ↗

Distinct Pathogenesis of Pancreatic Cancer Microvesicle–Associated Venous Thrombosis Identifies New Antithrombotic Targets In VivoSemantic proximity Read ↗

POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in miceSemantic proximity Read ↗

Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects.Semantic proximity Read ↗

Platelet polyphosphate and SARS-Cov-2 mRNA-vaccine-induced inflammatory side effects: a pilot studySemantic proximity Read ↗

RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice.Semantic proximity Read ↗

Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitorsSemantic proximity Read ↗

Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.