Article

Investigating the Structural Effects of Anti-Thrombin Anticoagulant Aptamers on Activation of Human Prothrombin

2025-01-27

Abstract excerpt

Disorders of the blood coagulation remain a leading cause of death and disability worldwide raising the search for therapeutic agents able to modulate the coagulation cascade. Different oligonucleotide aptamers have been selected against different coagulation factors and some of them are in preclinical or clinical studies. In particular, anti-thrombin aptamers are promising drugs as they inhibit the activity of th...

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Literature Corpus work: be26d526-c8a3-55d2-a40b-a3249095a14d
DOI: 10.1101/2025.01.24.634711

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