Article
Somatic genetic changes on chromosome 18 in breast carcinomas: is the DCC gene involved?
Oncogene - 1 Feb 1991
Devilee P, van Vliet M, Kuipers-Dijkshoorn N, Pearson P L, Cornelisse C J
Abstract excerpt
Recently, a gene has been isolated from the long arm of chromosome 18 which was shown to be frequently deleted in colorectal carcinomas and hence designated the DCC gene (Fearon et al., 1990). To explore the possible involvement of this gene in breast cancer, we have used 5 polymorphic DNA markers (one for 18p, and four for 18q) to examine the status of chromosome 18 in 49 primary breast carcinomas by comparing...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 18
- DNA, Neoplasm
- Female
- Gene Rearrangement
- Heterozygote
- Humans
- Oncogenes