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Article

Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.

Japanese journal of cancer research : Gann - 1 Oct 1997

Yokota T, Matsumoto S, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Nakamura Y, Emi M

Abstract excerpt

DPC4 and DCC, putative tumor suppressor genes implicated in the genesis of several types of human cancer, lie on the long arm of human chromosome 18. We examined 200 primary breast cancers for allelic losses on chromosome 18, using 15 microsatellite markers distributed along the long arm. Allelic loss was detected most frequently (29-30%) at loci mapped to 18q21. Deletion mapping of the 34 tumors showing partial...

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Source

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Identifiers

PMID: 9414657
DOI: 10.1111/j.1349-7006.1997.tb00315.x
PMCID: PMC5921283

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.PMID 9414657Read ↗

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Semantic proximity Read ↗

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Detailed deletion analysis of sporadic breast tumors defines an interstitial region of allelic loss on 17q25.Semantic proximity Read ↗

Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.Semantic proximity Read ↗

Genetic alterations of microsatellites on chromosome 18 in human breast carcinoma.Semantic proximity Read ↗

Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.Semantic proximity Read ↗

Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors.Semantic proximity Read ↗

Somatic genetic changes on chromosome 18 in breast carcinomas: is the DCC gene involved?Semantic proximity Read ↗

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Identification of a chromosome 18q gene that is altered in colorectal cancers.Semantic proximity Read ↗

Loss, mutation and deregulation of L3MBTL4 in breast cancers.Semantic proximity Read ↗

Linkage studies with 17q and 18q markers in a breast/ovarian cancer family.Semantic proximity Read ↗

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